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// Setup the masks for conversion const TInt64 yearMask = 100000000; const TInt monthMask = 1000000; const TInt dayMask = 10000; const TInt hoursMask = 100; const TInt minutesMask = 1; // Example individual components for the date // 2007-12-31 23:59 TInt year = 2007; TInt month = 12; TInt day = 31; TInt hours = 23; TInt minutes = 59; // Create the integer version of the date TInt64 dateInt = yearMask * year; // 200700000000 dateInt += monthMask * month; // 200712000000 dateInt += dayMask * day; // 200712310000 dateInt += hoursMask * hours; // 200712312300 dateInt += minutesMask * minutes; // 200712312359

Page 145: And in politics, the pharmaceutical industry . . . {Figures about the industry s clout, including the number of lobbyists, are cited frequently by the media. The information about spending $150 million a year in lobbying and $5 million just to lobby the FDA came from Robert Pear, Drug Companies Increase Spending on Efforts to Lobby Congress and Governments, New York Times, June 1, 2003.] Page 146: Hinchey specifically cited unprecedented activity . . . [The quote is from a press release issued by Congressman Hinchey on July 13, 2004.] Page 146: Tossing out years of government . . . [Robert Pear, In a Shift, Bush Moves to Block Medical Suits, New York Times, July 25, 2004, A1.] Page 147: There was, in fact, an explicit concern . . . [Robert Temple, Development of Drug Law, Regulations, and Guidance in the United States, in Governmental Regulation of Drugs, 1995, p. 1646.] Page 149: The Wall Street Journal in July 2004 reported . . . [Anna Wilde Mathews and Thomas M. Burton, After Medtronic Lobbying Push, the FDA Had Change of Heart, Wall Street Journal, July 9, 2004, A1.] Page 157: In a paper published in the American Journal of Political Science . . . [Daniel P. Carpenter, Groups, the Media, Agency Waiting Costs, and FDA Drug Approval, in American Journal of Political Science, July 2002, pp. 490 505.]

The ordered and unordered lists have many different display options available: Ordered lists can have their items preceded by the following:

200 200

known and generally accepted that HRT maintains bone density and if take-up were high enough HRT would afford a real hope of reducing age-speci c rates of fractures due to osteoporosis HRT has therefore been widely promoted and prescribed as a useful public health intervention for reducing osteoporosis Persistent concerns about the long-term safety of HRT (eg Beral et al 2003), as well as short-term side-effects experienced by many women, have limited long-term usage and recent adverse publicity about HRT safety has lead to many women abandoning HRT and has made many family doctors reluctant to continue long-term prescription In late 2003, the Medicines and Healthcare Products Regulatory Authority issued advice to doctors that HRT should no longer be used for the long-term prevention of osteoporosis in women over 50 years.

8.15,

acid is a precursor of coenzyme A (CoA) and CoA-containing moieties (eg acetyl-CoA and succinyl-CoA) are key intermediaries in many metabolic pathways Pantothenate is present as CoA in most animal and plant cells and so is widely distributed in foods Spontaneous cases of pantothenic acid de ciency do not occur Average UK intakes from food are around 55 mg/day with the highest consumers taking almost double this amount Over the counter supplements may provide a further 550 mg/day Pharmacological doses of calcium pantothenate have been suggested as a possible treatment for rheumatoid arthritis and lupus erythematosus and doses of 2000 10 000 mg/day have been used in trials of its ef cacy in this regard with almost no reports of toxic effects FSA (2003) suggest that a supplemental dose of 200 mg/day would not be expected to produce any harmful effects.

Could phyto-oestrogens offer a safer long-term alternative to HRT for maintaining bone health in elderly women In a recent review of phyto-oestrogens and bone health (Valtuena et al 2003), it was suggested that studies of the effects of phyto-oestrogens on bone health were still at an early stage and that supporting data were largely from in vitro experiments, animal studies and epidemiological associations Those studies directly investigating the effects of phyto-oestrogens on human bones in vivo have been of short duration, small size and have used various doses and preparations of phyto-oestrogens This review thus focused mainly upon the appropriate design and investigative approaches that should be used for future studies of the effects of phyto-oestrogens upon bone health.

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